Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor
Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor
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DOI：
10.1016/j.bmcl.2009.12.010
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发表时间：
2010-02-01
影响因子：
2.7
通讯作者：
Fujii, Ikuo
中科院分区：
文献类型：
--
作者：
El-Haggar, Radwan;Kamikawa, Ken;Fujii, Ikuo
基于与粒细胞集落刺激因子受体（G-CSFR）结合的肽（P8-2KAQ）的结构信息，设计了具有联芳基支架的小配体，并评价了它们的结合亲和力。(C)2009爱思唯尔有限公司保留所有权利。
Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated. (C) 2009 Elsevier Ltd. All rights reserved.