Amide proton transfer (APT) magnetic resonance imaging of prostate cancer: comparison with Gleason scores
Amide proton transfer (APT) magnetic resonance imaging of prostate cancer: comparison with Gleason scores
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DOI：
10.1007/s10334-016-0537-4
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发表时间：
2016-08-01
影响因子：
2.3
通讯作者：
Honda, Hiroshi
中科院分区：
文献类型：
--
作者：
Takayama, Yukihisa;Nishie, Akihiro;Honda, Hiroshi
为评价酰胺质子转移（APT）显像在前列腺癌（Pca）Gleason评分（GS）中的应用价值，将66例经病理证实的前列腺癌按GS分为4组：GS-6（3 + 3）、GS-7（3 + 4/4 + 3）、GS-8（4 + 4）和GS-9（4 + 5/5 + 4）。通过单向方差分析和Tukey's HSD事后检验比较每个GS组的APT信号强度（APT SI）和表观扩散系数（ADC）值。APT SI（%）和ADC值（x10（-3）mm（2）/s）的平均值和标准差如下：GS-6，2.48 +/- 0.59和1.16 +/- 0.26; GS-7，5.17 +/- 0.66和0.92 +/- 0.18; GS-8，2.56 +/- 0.85和0.86 +/- 0.17; GS-9，1.96 +/- 0.75和0.85 +/- 0.18。GS-7组的APT SI最高，且GS-6和GS-7组与GS-7和GS-9组之间存在显著差异（p < 0.05）。GS-6组的ADC值显著高于GS-7、GS-8和GS-9组（p < 0.05），但GS-7、GS-8和GS-9组之间无显著差异。
To evaluate the utility of amide proton transfer (APT) imaging in estimating the Gleason score (GS) of prostate cancer (Pca).Sixty-six biopsy-proven cancers were categorized into four groups according to the GS: GS-6 (3 + 3); GS-7 (3 + 4/4 + 3); GS-8 (4 + 4) and GS-9 (4 + 5/5 + 4). APT signal intensities (APT SIs) and apparent diffusion coefficient (ADC) values of each GS group were compared by one-way analysis of variance with Tukey's HSD post hoc test.The mean and standard deviation of the APT SIs (%) and ADC values (x10(-3) mm(2)/s) were as follows: GS-6, 2.48 +/- 0.59 and 1.16 +/- 0.26; GS-7, 5.17 +/- 0.66 and 0.92 +/- 0.18; GS-8, 2.56 +/- 0.85 and 0.86 +/- 0.17; GS-9, 1.96 +/- 0.75 and 0.85 +/- 0.18, respectively. The APT SI of the GS-7 group was highest, and there were significant differences between the GS-6 and GS-7 groups and the GS-7 and GS-9 groups (p < 0.05). The ADC value of the GS-6 group was significantly higher than each value of the GS-7, GS-8, and GS-9 groups (p < 0.05), but no significant differences were obtained among the GS-7, GS-8, and GS-9 groups.The mean APT SI in Pca with a GS of 7 was higher than that for the other GS groups.