Drugs from the sea: Harvesting the results of aeons of chemical evolution
Drugs from the sea: Harvesting the results of aeons of chemical evolution
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DOI：
10.1016/s1357-4310(97)01059-9
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发表时间：
1997-07-01
期刊：
影响因子：
--
通讯作者：
Wallace, RW
中科院分区：
文献类型：
--
作者：
Wallace, RW
尽管组合化学最近的发展可以快速产生数千种新的化学物质，但制药行业仍然希望在自然环境中发现新的化合物，以扩展我们化学想象的边界。多年来，人们一直在陆地环境中开采这类化合物，并取得了巨大成功。现在世界的海洋开始产生隐藏的宝藏。这些化学品中有许多结构复杂，现代有机化学家试图模仿自然界的合成多功能性，将他们的能力发挥到了极限。在未来，这些海洋化合物可能会产生全新的药物类别，这将对我们治疗人类疾病的能力做出宝贵的贡献。
Despite the recent development of combinatorial chemistry for the rapid generation of thousands of new chemicals, the pharmaceutical industry still looks to the natural environment to uncover novel compounds that extend the boundaries of our chemical imagination. The terrestrial environment has been mined for such compounds for many years with great success. Now the world's oceans are beginning to yield hidden treasures. Many of these chemicals are structurally complex, stretching the prowess of modern organic chemists to their limits as they attempt to mimic the synthetic versatility of nature. In the future, these marine compounds are likely to yield entirely new classes of drugs that will be a valuable contribution to our ability to treat human disease.