Microenvironment-controlled encapsulation (MiCE) process: effects of PLGA concentration, flow rate, and collection method on microcapsule size and morphology.
Microenvironment-controlled encapsulation (MiCE) process: effects of PLGA concentration, flow rate, and collection method on microcapsule size and morphology.
复制标题
微环境控制封装 (MiCE) 过程：PLGA 浓度、流速和收集方法对微胶囊尺寸和形态的影响。
DOI：
10.1007/s11095-007-9456-4
复制
发表时间：
2008
影响因子：
3.7
通讯作者：
Park,Kinam
中科院分区：
文献类型：
--
作者：
Snider,Connie;Lee,Sang-Youp;Yeo,Yoon;Grégori,GéraldJ;Robinson,JPaul;Park,Kinam
PurposeTo evaluate the real-time effects of formulation and instrumental variables on microcapsule formation via natural jet segmentation, a new microencapsulation system termed the microenvironment-controlled encapsulation (MiCE) process was developed.MethodsA modified flow cytometer nozzle hydrodynamically focuses an inner drug and outer polymer solution emanating from a coaxial needle assembly into a two-layer compound jet. Poly(lactic-co-glycolic acid) (PLGA) dissolved in a water-miscible organic solvent resulted in formation of reservoir-type microcapsules by interfacial phase separation induced at the boundary between the PLGA solution and aqueous sheath.ResultsThe MiCE process produced microcapsules with mean diameters ranging from 15–25 μm. The resultant microcapsule size distribution and number of drug cores existing within each microcapsule was largely influenced by the PLGA concentration and microcapsule collection method. Higher PLGA concentrations yielded higher mean diameters of single-core microcapsules. Higher drug solution flow rates increased the core size, while higher PLGA solution flow rates increased the PLGA film thickness.ConclusionThe MiCE microencapsulation process allows effective monitoring and control of the instrumental parameters affecting microcapsule production. However, the microcapsule collection method in this process needs to be further optimized to obtain microcapsules with desired morphologies, precise membrane thicknesses, high encapsulation efficiencies, and tight size distributions.
