The effect of graded hypothermia on hypoxic‐ischemic brain damage: a neuropathologic study in the neonatal rat.
The effect of graded hypothermia on hypoxic‐ischemic brain damage: a neuropathologic study in the neonatal rat.
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分级低温对缺氧缺血性脑损伤的影响：新生大鼠的神经病理学研究。
DOI：
10.1161/01.str.14.6.929
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发表时间：
1983
期刊：
影响因子：
8.3
通讯作者：
J. Towfighi
中科院分区：
文献类型：
--
作者：
R. Young;T. Olenginski;S. Yagel;J. Towfighi
为了研究新生儿动物低温过程中神经病理损伤与脑代谢改变的关系，我们将7日龄的Sprague-Dawley大鼠单侧颈总动脉结痂并在37℃、29℃和21℃下进行缺氧治疗。37℃时，大鼠的顶盖和同侧大脑半球大面积梗死，脑ATP明显耗竭。29℃时，脑内ATP无明显变化；神经病理损伤仅限于大脑皮层较深层的少数坏死区域。21℃组大鼠未见组织学损伤。深度低温可以通过降低脑代谢需求来预防脑水肿和与缺氧缺血性损伤相关的可见神经病理损伤。中度低温能提供部分但不完全的保护；而在常温下，缺氧缺血性损伤的程度是完全明显的。
To investigate the relationship between neuropathologic damage and cerebral metabolic alterations during hypothermia in the neonatal animal, 7 day old Sprague-Dawley rats were subjected to unilateral common carotid artery ligation and hypoxia at 37 degrees C, 29 degrees C, and 21 degrees C. At 37 degrees C, animals had extensive infarction of tectum and ipsilateral cerebral hemisphere, and marked depletion of brain ATP. At 29 degrees C, there was no significant change in brain ATP; neuropathologic damage was limited to a few areas of necrosis in the deeper layers of cerebral cortex. No histologic injury was seen in the 21 degrees C group of rats. Profound hypothermia may prevent cerebral edema and visible neuropathologic damage associated with hypoxic-ischemic injury by decreasing cerebral metabolic demands. Moderate hypothermia confers a partial, but incomplete degree of protection; whereas during normothermia, the full extent of hypoxicischemic injury is manifest.