Circulating Dehydroepiandrosterone Sulfate Concentrations during the Menopausal Transition
Circulating Dehydroepiandrosterone Sulfate Concentrations during the Menopausal Transition
复制标题
DOI：
10.1210/jc.2009-0386
复制
发表时间：
2009-08-01
影响因子：
5.8
通讯作者：
Lasley, Bill
中科院分区：
文献类型：
--
作者：
Crawford, Sybil;Santoro, Nanette;Lasley, Bill
内容：一份来自全国妇女研究的先前报告指出，在绝经过渡期，硫酸脱氢表雄酮（DHEAS）的升高使用了三次年度访视的数据。目的：我们的目的是检查DHEAS随时间和卵巢老化的变化，将原始分析扩展到包括10年的年度数据。设计：对基线数据进行纵向观察研究和横断面分析。DHEAS，年龄，绝经状态，种族，吸烟，体重和身高进行了评估，在2886名妇女从五个种族，年龄在42 - 52岁的入口。子宫切除术，双侧卵巢切除术，和激素的使用excluded.Results：横断面分析显示，在基线循环对数转换DHEAS的线性下降，随着年龄的增加，无论是整个队列（每年2.81%）或个别种族。在纵向线性混合模型中观察到与基线年龄（每年下降2.44%）相似的负相关性，包括从绝经前到绝经后期的观察结果，每年额外下降0.33%。与此相反，当对相同的妇女进行卵巢状态分析时，检测到DHEAS的晚期转换升高。平均循环DHEAS水平在绝经早期和晚期过渡之间的平均增加，超出了衰老预测的变化，为3.95%，随后在绝经后期平均下降3.96%。大约84.5%的妇女估计妇女内增加DHEAS从绝经前/早期围绝经期晚期围绝经期/早期postmenopause.Conclusion：这些观察强调横截面和纵向研究之间的差异，并考虑卵巢状态的重要性。关于肾上腺对中年妇女性类固醇的贡献的进一步调查是必要的。（临床内分泌代谢杂志94：2945 - 2951，2009）
Context: A previous report from the Study of Women Across the Nation indicated a rise in dehydroepiandrosterone sulfate (DHEAS) during the menopausal transition using data from three annual visits.Objective: Our objective was to examine changes in DHEAS with chronological and ovarian aging, expanding the original analyses to include 10 yr of annual data.Design: A longitudinal observational study and cross-sectional analyses of baseline data were conducted.Outcome Measures and Subjects: DHEAS, age, menopause status, ethnicity, smoking, weight, and height were assessed in 2886 women from five ethnic groups aged 42-52 yr at entry. Hysterectomy, bilateral oophorectomy, and hormone use were excluded.Results: Cross-sectional analysis at baseline showed a linear decline in circulating log-transformed DHEAS with increasing age for either the entire cohort (2.81% per year) or for individual ethnicities. A similar negative association with baseline age (2.44% decline per year) was seen in longitudinal linear mixed modeling including observations from premenopause through late postmenopause, an additional 0.33% decline/year. In contradistinction, a late-transition rise in DHEAS was detected when the same women were analyzed by ovarian status. The average increase in mean circulating DHEAS level between early and late menopause transition, beyond changes predicted by aging, was 3.95%, followed by an average decline of 3.96% during the late postmenopause. Approximately 84.5% of the women had an estimated within-woman increase in DHEAS from premenopause/early perimenopause to late perimenopause/early postmenopause.Conclusion: These observations underscore differences between cross-sectional and longitudinal studies and the importance of considering ovarian status. Additional investigations regarding adrenal contribution to sex steroids in mid-aged women are warranted. (J Clin Endocrinol Metab 94: 2945-2951, 2009)