Effect of streptozotocin-induced diabetes on daily expression of per2 and dbp in the heart and liver and melatonin rhythm in the pineal gland of Wistar rat
Effect of streptozotocin-induced diabetes on daily expression of per2 and dbp in the heart and liver and melatonin rhythm in the pineal gland of Wistar rat
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DOI：
10.1007/s11010-005-5323-y
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发表时间：
2005-02-01
影响因子：
4.3
通讯作者：
Ravingerová, T
中科院分区：
文献类型：
--
作者：
Herichová, I;Zeman, M;Ravingerová, T
昼夜节律系统是一个灵活的框架，允许对生理功能进行适当的调整，以适应定期变化的环境。用于同步昼夜节律系统组成部分的途径已被证明容易受到病理生理条件的影响。在我们的研究中，我们研究了链脲佐剂（STZ）诱导的糖尿病对8周龄Wistar大鼠心脏和肝脏中褪黑激素合成和per2和dbp表达水平的昼夜节律系统功能的影响。测定对照组和stz处理动物生物钟基因per2和转录因子dbp的节律模式。链脲佐菌素对肝脏per2表达的影响比对心脏per2表达的影响更大。在肝脏和心脏中观察到dbp表达节律明显的期进。反映主时钟相位的褪黑激素节律不受STZ应用的影响。心脏和肝脏中per2和dbp表达的变化意味着输入通路或外周振荡的改变，可能对所分析器官的功能产生影响。
The circadian system is a flexible framework allowing a proper adjustment of physiological functions to the regularly changing environment. Pathways that are used to synchronize components of the circadian system have been shown to be susceptible to pathophysiological conditions. In our study, we investigated effects of streptozotocin (STZ)-induced diabetes mellitus on function of the circadian system at the level of melatonin synthesis and expression of per2 and dbp in the heart and liver in 8-week-old Wistar rats. Rhythmic pattern of clock gene per2 and transcription factor dbp in controls and STZ-treated animals was determined. Streptozotocin administration had a more substantial effect on per2 expression in the liver than in the heart. Pronounced phase advance in the rhythm of dbp expression in both the liver and the heart was observed. The melatonin rhythm reflecting the phase of the master clock was not affected by STZ application. Changes in per2 and dbp expression in the heart and liver imply alterations in input pathway or peripheral oscillators with possible consequences on function of analysed organs.