GB virus C/hepatitis G virus infection in southern China.
GB virus C/hepatitis G virus infection in southern China.
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中国南方地区的GB病毒C/G型肝炎病毒感染。
DOI：
10.1093/infdis/175.1.168
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
S. Iino
中科院分区：
文献类型：
--
作者：
R. Wu;M. Mizokami;K. Cao;T. Nakano;X. Ge;S. Wang;E. Orito;K. Ohba;M. Mukaide;K. Hikiji;J. Lau;S. Iino
对南宁市静脉吸毒者（IVDUs）、肝脏疾病患者和献血者中GB病毒C/ G型肝炎病毒（GBV-C/HGV）感染情况进行了调查。采用反转录聚合酶链反应法检测GBV-C/HGV RNA，引物来源于5'-非翻译区。85名IVDUs中有64人、80名肝病患者中有20人、50名献血者中有1人检测到GBV-C/HGV RNA。在IVDUs中，GBV-C/HGV感染与丙型肝炎病毒（HCV）抗体和乙型肝炎表面抗原（HBsAg）相关。通过分子进化分析确定并分析了11个核苷酸序列。在系统发育树中，分离株被划分为3个簇，其中GBV-C和HGV被划分为2个簇。这些数据表明，GBV-C/HGV感染在中国IVDUs中很常见，但在没有HBsAg或抗- hcv的肝病患者中并不常见，并且存在一个新的GBV-C/HGV群体。
The prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection among intravenous drug users (IVDUs), patients with liver diseases, and blood donors in Nanning, southern China was studied. GBV-C/HGV RNA was detected by reverse transcription polymerase chain reaction with primers derived from the 5'-untranslated region. GBV-C/HGV RNA was detected in 64 of 85 IVDUs, 20 of 80 persons with liver disease, and 1 of 50 blood donors. Among IVDUs, GBV-C/HGV infection was associated with antibodies to hepatis C virus (HCV) and with hepatitis B surface antigen (HBsAg). Eleven nucleotide sequences were determined and analyzed by molecular evolutionary analysis. In a phylogenetic tree, the isolates were grouped in three clusters with GBV-C and HGV grouped in two clusters. These data indicate that GBV-C/HGV infection is common in China among IVDUs but uncommon among persons with liver disease without HBsAg or anti-HCV and that there is a new group of GBV-C/HGV.