Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.
Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.
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发表时间：
1991-09
期刊：
影响因子：
3.3
通讯作者：
R. Ellis;Dean M. Jacobson;-H.;Horvitz
中科院分区：
文献类型：
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作者：
R. Ellis;Dean M. Jacobson;-H.;Horvitz
程序性细胞死亡后，细胞尸体被吞噬并迅速被相邻细胞降解。为了发生降解，吞噬细胞必须识别、吞噬和消化垂死细胞的尸体。在此之前，已知有三个基因参与消除秀丽隐杆线虫中的细胞尸体：ced-1、ced-2和nuc-1。我们已经确定了五个在这个过程中发挥作用的新基因：ced-5，ced-6，ced-7，ced-8和ced-10。电子显微镜研究表明，这些基因中的每一个突变都可以阻止吞噬，这表明这些基因要么是其他细胞识别尸体所必需的，要么是吞噬作用的启动所必需的。根据我们对双突变体的研究，这些基因可以分为两组。只有其中一组基因发生突变的动物，其未被吞噬的细胞尸体相对较少。相比之下，在这两组基因中都有突变的动物有许多未被吞噬的尸体。这些观察结果表明，这两组基因参与了吞噬细胞尸体的不同和部分冗余的过程。
After programmed cell death, a cell corpse is engulfed and quickly degraded by a neighboring cell. For degradation to occur, engulfing cells must recognize, phagocytose and digest the corpses of dying cells. Previously, three genes were known to be involved in eliminating cell corpses in the nematode Caenorhabditis elegans: ced-1, ced-2 and nuc-1. We have identified five new genes that play a role in this process: ced-5, ced-6, ced-7, ced-8 and ced-10. Electron microscopic studies reveal that mutations in each of these genes prevent engulfment, indicating that these genes are needed either for the recognition of corpses by other cells or for the initiation of phagocytosis. Based upon our study of double mutants, these genes can be divided into two sets. Animals with mutations in only one of these sets of genes have relatively few unengulfed cell corpses. By contrast, animals with mutations in both sets of genes have many unengulfed corpses. These observations suggest that these two sets of genes are involved in distinct and partially redundant processes that act in the engulfment of cell corpses.