How and Where are Drugs Absorbed
How and Where are Drugs Absorbed
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DOI：
10.1002/9780470571224.pse038
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发表时间：
2010-03
期刊：
影响因子：
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通讯作者：
M. Bermejo;I. González-Álvarez
中科院分区：
文献类型：
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作者：
M. Bermejo;I. González-Álvarez
药物必须与其作用位点或治疗靶点的受体相互作用才能发挥其药理作用或毒性作用。因此，药物的吸收是决定药物药理作用的重要环节。本文着重介绍药物进入体内必须跨越的生物屏障、药物吸收机制以及给药途径的生理特性对吸收速率和程度的影响。关键词：药物;吸收机制;给药途径;被动扩散;内吞作用
A drug must interact with its receptors at their action sites or therapeutic target to exert its pharmacological or toxic effects. Therefore, the absorption of drug is an essential step which determines pharmacologic effects of drug. This article focuses on the biological barriers that the drug must cross in order to enter the body, drug absorption mechanisms, and influence of physiological characteristics of the administration route on absorption rate and extent. Keywords: drugs; absorption mechanisms; administration routes; passive diffusion; endocytosis