Improvements to CluSTr: the database of SWISS-PROT plus TrEMBL protein clusters
Improvements to CluSTr: the database of SWISS-PROT plus TrEMBL protein clusters
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DOI：
10.1093/nar/gkg035
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Apweiler, R
中科院分区：
文献类型：
--
作者：
Kriventseva, EV;Servant, F;Apweiler, R
CluSTr数据库(http：//www.虾。交流电。UK/clustr/)提供了将SWISSPROT+REMP1蛋白质自动分类为相关蛋白质组的功能。聚类是基于使用史密斯·沃特曼算法对蛋白质之间的所有成对序列比较进行分析的。对不同水平的蛋白质相似性进行的分析，产生了簇的分级组织。有关聚集蛋白质的结构域内容的信息通过InterPro资源提供。引入的InterPro精简图形视图简化了对所表示的域体系结构的可视化分析。集成的应用程序允许用户可视化和编辑多个比对并构建序列分歧树。还提供了蛋白质数据库(PDB)和蛋白质同源衍生二级结构(HSSP)中相关结构数据的链接。
The CluSTr database (http: / / www. ebi. ac. uk/ clustr/) offers an automatic classification of SWISSPROT + TrEMBL proteins into groups of related proteins. The clustering is based on analysis of all pair-wise sequence comparisons between proteins using the Smith Waterman algorithm. The analysis, carried out on different levels of protein similarity, yields a hierarchical organization of clusters. Information about domain content of the clustered proteins is provided via the InterPro resource. The introduced InterPro condensed graphical view simplifies the visual analysis of represented domain architectures. Integrated applications allow users to visualize and edit multiple alignments and build sequence divergence trees. Links to the relevant structural data in Protein Data Bank ( PDB) and Homology derived Secondary Structure of Proteins (HSSP) are also provided.