Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
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DOI：
10.1016/j.radonc.2017.05.003
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发表时间：
2017-09-01
影响因子：
5.7
通讯作者：
Vozenin, Marie-Catherine
中科院分区：
文献类型：
--
作者：
Montay-Gruel, Pierre;Petersson, Kristoffer;Vozenin, Marie-Catherine
本研究首次表明，脑外伤后正常脑组织毒性可随着剂量率的增加而降低。平均剂量率在100 Gy/s以上的WBI后，空间记忆得以保留，而10 Gy的常规放疗剂量率（0.1 Gy/s）的WBI完全损害了空间记忆。(C) 2017 Elsevier B.V.版权所有
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory. (C) 2017 Elsevier B.V. All rights reserved.