Impact of vitamin A supplementation on the incidence of infection in elderly nursing-home residents: a randomized controlled trial.
Impact of vitamin A supplementation on the incidence of infection in elderly nursing-home residents: a randomized controlled trial.
复制标题
补充维生素 A 对老年疗养院居民感染发生率的影响：一项随机对照试验。
DOI：
10.1093/ageing/21.6.435
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发表时间：
1992
期刊：
影响因子：
6.7
通讯作者：
Clement,L
中科院分区：
文献类型：
--
作者：
Murphy,S;WestJr,KP;Greenough3rd,WB;Cherot,E;Katz,J;Clement,L
本研究的目的是确定维生素A补充剂是否能降低老年疗养院居民细菌感染的发生率。109名患者在一家学术附属疗养院参加了一项双盲、安慰剂对照试验。五十六例患者接受含1000 IU维生素A的单粒胶囊（安慰剂），53例患者接受含200000 IU维生素A的单粒胶囊。在给药后90天内对抗生素治疗的感染进行计数，并表示每1000天随访的感染率。总共有42例接受抗生素治疗的感染，每组21例。维生素A组和安慰剂组的感染率分别为每1000天随访4.7和4.3（相对风险1.1; 95% CI 0.6，2.0）。这项研究的结果并不支持维生素A补充剂在预防体弱的老年疗养院患者感染中的作用。
The aim of this study was to determine if vitamin A supplementation reduces the incidence of bacterial infections among elderly nursing-home residents. One hundred and nine patients were enrolled into a double-masked, placebo-controlled trial at an academically affiliated nursing home. Fifty-six patients received a single capsule containing 1000 IU of vitamin A (placebo) and 53 received a single capsule containing 200000 IU of vitamin A. Antibiotic-treated infections were enumerated for 90 days after dosing and infection rates were expressed per 1000 days of follow-up. There were 42 antibiotic-treated infections altogether, 21 in each group. The infection rates in the vitamin A and placebo groups were 4.7 and 4.3 per 1000 days of follow-up, respectively (relative risk 1.1; 95% CI 0.6, 2.0). The findings of this study do not support a role for vitamin A supplements for the prevention of infections among frail elderly nursing-home patients.