DIFFERENTIAL-EFFECTS OF THE PHARMACOLOGICAL MANIPULATION OF SEROTONIN SYSTEMS ON COCAINE AND AMPHETAMINE SELF-ADMINISTRATION IN RATS
DIFFERENTIAL-EFFECTS OF THE PHARMACOLOGICAL MANIPULATION OF SEROTONIN SYSTEMS ON COCAINE AND AMPHETAMINE SELF-ADMINISTRATION IN RATS
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DOI：
10.1016/0024-3205(89)90418-9
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发表时间：
1989-01-01
期刊：
影响因子：
6.1
通讯作者：
GOLDBERG, SR
中科院分区：
文献类型：
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作者：
PORRINO, LJ;RITZ, MC;GOLDBERG, SR
比较了服用血清素药物对大鼠在每日 4 小时的 FR-10 强化方案中自我施用可卡因和安非他明的输注率的影响。用氟西汀（2.5、5 和 10 mg/kg）（一种血清素再摄取抑制剂）进行预处理，可显着降低安非他明维持的反应率，但对任何测试剂量的可卡因维持的反应没有影响。用肉桂色林（5-羟色胺受体拮抗剂）（3、10和17.5 mg/kg）进行预处理，可降低最高测试剂量下的安非他明自我给药率，并且对可卡因自我给药也没有影响。这些数据表明卡卡因和安非他明自我给药对中枢血清素系统的药理学操作的敏感性不同。它们与生化数据一致，生化数据表明苯丙胺类药物（而非可卡因类药物）的增强效力与其在血清素结合位点的效力之间存在负相关。
The effects of the administration of serotonergic drugs on infusion rates of rats self-administering cocaine and amphetamine on an FR-10 schedule for reinforcement in daily 4 hour sessions were compared. Pretreatment with fluoxetine (2.5, 5, and 10 mg/kg), an inhibitor of serotonin reuptake, significantly decreased rates of responding maintained by amphetamine, but had no effect on responding maintained by cocaine at any of the doses tested. Pretreatment with cinanserin (3, 10, and 17.5 mg/kg), a serotonergic receptor antagonists, decreased rates of amphetamine self-administration at the highest dose tested, and also had no effect on cocaine self-administration. These data suggest a differential sensitivity of cacaine and amphetamine self-administration to pharmacological manipulation of central serotonin systems. They are consistent with biochemical data which demonstrates a negative correlation between the reinforcing potency of amphetamine-like drugs, but not cocaine-like drugs and their potency at serotonin binding sites.