A new hypothesis about the origin of uterine fibroids based on gene expression profiting with microarrays
A new hypothesis about the origin of uterine fibroids based on gene expression profiting with microarrays
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DOI：
10.1016/j.ajog.2005.12.059
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发表时间：
2006-08-01
影响因子：
9.8
通讯作者：
Segars, James H.
中科院分区：
文献类型：
--
作者：
Leppert, Phyllis C.;Catherino, William H.;Segars, James H.
本文将讨论一些最近的见解，我们的微阵列研究的基础上，强调的作用，细胞外基质，转化生长因子β和胶原蛋白结构在纤维瘤形成。这些研究使人们认识到肌瘤和瘢痕疙瘩之间的分子相似性。总的来说，这些观察结果表明了一种基于对组织修复的异常反应的纤维瘤发展模型，导致无序愈合和形成改变的细胞外基质。(c)2006 Mosby，Inc. All rights reserved.
This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix. (c) 2006 Mosby, Inc. All rights reserved.