Skeletal manifestations of systemic autoimmune diseases
Skeletal manifestations of systemic autoimmune diseases
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DOI：
10.1097/med.0b013e328340533d
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发表时间：
2010-12-01
影响因子：
3.2
通讯作者：
Alele, Jimmy D.
中科院分区：
文献类型：
--
作者：
Kamen, Diane L.;Alele, Jimmy D.
综述的目的在某些全身性自身免疫性疾病的患者中，年轻时发生骨质疏松性骨折和骨坏死的风险增加。这些疾病中骨密度和骨完整性的丧失通常不能仅用传统的风险因素来解释。本文就类风湿性关节炎和系统性红斑狼疮作一综述，两种全身性自身免疫性疾病，其中骨骼表现已得到很好的描述。最近的发现最近有证据表明，自身免疫及其相关的炎症和维生素D缺乏症在不良骨骼效应的发病机制中起关键作用。总结了解这些过程对预防和治疗骨质疏松症和骨坏死具有重要意义，自身免疫性疾病患者。
Purpose of reviewThere is an increased risk of osteoporotic fractures and osteonecrosis often at a young age among patients with certain systemic autoimmune diseases. The loss of bone mineral density and bone integrity seen with these diseases often cannot be explained by traditional risk factors alone. In this review, we focus on rheumatoid arthritis and systemic lupus erythematosus, two systemic autoimmune diseases in which skeletal manifestations have been well described.Recent findingsThere is recent evidence that autoimmunity and its associated inflammation and vitamin D deficiency play key roles in the pathogenesis of adverse skeletal effects.SummaryUnderstanding these processes carries implications for the prevention and treatment of osteoporosis and osteonecrosis among patients with autoimmune diseases.