Role of rs454214 in Personality mediated Depression and Subjective Well-being
Role of rs454214 in Personality mediated Depression and Subjective Well-being
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rs454214 在人格介导的抑郁和主观幸福感中的作用
DOI：
10.1038/s41598-020-62486-x
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发表时间：
2020-03-30
影响因子：
4.6
通讯作者：
Li, Xingwang
中科院分区：
文献类型：
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作者：
Hou, Binyin;Ji, Lei;Li, Xingwang
快乐和抑郁是相互联系的，都是遗传的，而人格作为它们的重要预测因子，与它们共享遗传基础。我们推测，抑郁症的遗传因素可以影响抑郁症状（DS）和主观幸福感（SWB），而人格特质在这一过程中发挥重要作用。本研究共纳入878名汉族大学新生和384名汉族抑郁症患者。使用AGENA MassARRAY iPLEX技术对SNP进行基因分型，我们研究了一种重要的MDD变异rs 454214。采用相关、关联和中介分析等方法，试图揭示主观幸福感、抑郁量表、人格特质与遗传变异之间的复杂关系。关联分析表明rs 454214不仅与主观幸福感和抑郁量表有关（P < 0.05），而且可能与抑郁障碍有关。中介效应分析表明，rs 454214对主观幸福感和抑郁量表没有直接影响，但通过人格特质对主观幸福感和抑郁量表有显著的间接影响，即，外向性、神经质、情感性和经验开放性或主观幸福感、外向性、神经质和情感性。这项研究发现了快乐和抑郁的共同遗传基础;如果将人格特质作为中介因素，因果过程可以得到更好的解释。
Happiness and depression are interlinked and both heritable, while personality, as an important predictor of them, shares the genetic basis with them. We conjecture that genetic factors of depression can affect both depressive symptoms (DS) and subjective well-being (SWB), while personality traits play important roles in mediating this process. In this study, 878 Han Chinese college freshmen and 384 Han Chinese patients with the major depressive disorder (MDD) were included. SNPs were genotyped using AGENA MassARRAY iPLEX technology and we investigated an important MDD variant rs454214. Correlation, association and mediation analysis were employed, aiming to decipher the complex relationship between SWB, DS, personality traits and the genetic variant. Association study indicated that rs454214 was not only associated with both SWB and DS (P < 0.05), but also possibly linked to MDD. Mediational analysis showed that rs454214 had no direct effect on SWB and DS, but had a significant indirect effect through personality traits, i.e., Extraversion, Neuroticism, Agreeableness and Openness to Experience or SWB, Extraversion, Neuroticism and Agreeableness for DS. This study found a shared genetic basis for happiness and depression; the causal process could be better explained if personality traits are taken as mediating factors.