Developmental Pathways of Cardiac Fibroblasts.
Developmental Pathways of Cardiac Fibroblasts.
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DOI：
10.1101/cshperspect.a037184
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发表时间：
2019-09
影响因子：
7.2
通讯作者：
M. Tallquist
中科院分区：
文献类型：
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作者：
M. Tallquist
心脏成纤维细胞和纤维化有助于心脏衰竭的发病机制，一个普遍的死亡原因。因此，大多数关于心脏成纤维细胞的现有信息都集中在心脏损伤后的功能和行为上。对这些细胞的发育和稳态作用所需的信号和转录网络了解较少。这篇综述致力于描述我们目前对心脏成纤维细胞发育的理解。我详细心脏成纤维细胞形成过程中的胚胎发生，包括发现心脏成纤维细胞的第二个胚胎起源。关于心脏成纤维细胞发育所必需的基因的作用提供了额外的信息。值得注意的是，这些成纤维细胞祖细胞的细胞命运规范仍然存在许多问题，希望本文的综述将为今后有关这一主题的研究提供基础。
Cardiac fibroblasts and fibrosis contribute to the pathogenesis of heart failure, a prevalent cause of mortality. Therefore, a majority of the existing information regarding cardiac fibroblasts is focused on their function and behavior after heart injury. Less is understood about the signaling and transcriptional networks required for the development and homeostatic roles of these cells. This review is devoted to describing our current understanding of cardiac fibroblast development. I detail cardiac fibroblast formation during embryogenesis including the discovery of a second embryonic origin for cardiac fibroblasts. Additional information is provided regarding the roles of the genes essential for cardiac fibroblast development. It should be noted that many questions remain regarding the cell-fate specification of these fibroblast progenitors, and it is hoped that this review will provide a basis for future studies regarding this topic.