Liquid-liquid chromatography in enantioseparations
Liquid-liquid chromatography in enantioseparations
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DOI：
10.1016/j.chroma.2020.461345
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发表时间：
2020-08-30
影响因子：
4.1
通讯作者：
Tong，Shengqiang
中科院分区：
文献类型：
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作者：
Tong，Shengqiang
现代液-液色谱主要指以下两种色谱装置：基于流体动力学平衡系统的逆流色谱和基于流体静力学平衡系统的离心分配色谱。本文综述了近年来液-液色谱分离对映体的研究进展，包括分离机理、手性选择剂、两相溶剂体系、提高峰分辨率的方法以及应用前景。展望了液-液色谱在对映体分离中的应用前景。
Modern liquid-liquid chromatography mainly refers to the following two kinds of chromatographic apparatuses: countercurrent chromatography based on hydrodynamic equilibrium systems and centrifugal partition chromatography based on hydrostatic equilibrium systems. In this paper, the recent advancements in enantioseparations by liquid-liquid chromatography, including the separation mechanism, chiral selector, two-phase solvent system, methods to improve the peak resolution and recent applications, are reviewed. The future outlook for liquid-liquid chromatography in enantioseparations is also proposed.