Neurologic Consequences of Neonatal Necrotizing Enterocolitis
Neurologic Consequences of Neonatal Necrotizing Enterocolitis
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DOI：
10.1159/000525378
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发表时间：
2022-09-01
影响因子：
2.9
通讯作者：
Chang, Jill
中科院分区：
文献类型：
--
作者：
Berken, Jonathan A. A.;Chang, Jill
坏死性小肠结肠炎(NEC)是早产儿的一种严重的胃肠道疾病，具有很高的死亡率和发病率。NEC存活下来的儿童被证明表现出神经发育迟缓，结果比单独早产儿严重得多。导致NEC相关神经损伤的途径尚不清楚，限制了预防和保护策略的发展。本文就NEC相关性脑损伤的临床和实验研究现状作一综述。我们描述了NEC的当前流行病学，报道了幸存者的长期神经发育结果，并提出了NEC脑损伤的发病机制。重点介绍了NEC中缺氧缺血、营养、感染、肠道炎症和大脑发育之间的潜在联系。
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant with high mortality and morbidity. Children who survive NEC have been shown to demonstrate neurodevelopmental delay, with significantly worse outcomes than from prematurity alone. The pathways leading to NEC-associated neurological impairments remain unclear, limiting the development of preventative and protective strategies. This review aims to summarize the existing clinical and experimental studies related to NEC-associated brain injury. We describe the current epidemiology of NEC, reported long-term neurodevelopmental outcomes among survivors, and proposed pathogenesis of brain injury in NEC. Highlighted are the potential connections between hypoxia-ischemia, nutrition, infection, gut inflammation, and the developing brain in NEC.