Altered transcriptional activity of c-fos promoter plasmids in v-raf-transformed NIH 3T3 cells.
Altered transcriptional activity of c-fos promoter plasmids in v-raf-transformed NIH 3T3 cells.
复制标题
v-raf 转化的 NIH 3T3 细胞中 c-fos 启动子质粒的转录活性发生改变。
DOI：
10.1128/mcb.10.11.6073-6078.1990
复制
发表时间：
1990
影响因子：
5.3
通讯作者：
Ziff,EB
中科院分区：
文献类型：
--
作者：
Siegfried,Z;Ziff,EB
在用 v-raf（丝氨酸/苏氨酸激酶 Raf-1 的致癌对应物）转化的细胞中，c-fospromoter 的调节元件在细胞生长或刺激条件下具有活性，而在未转化的对照细胞中它们则处于非活性状态。这表明 v-raft 通过解除早期反应基因的转录调控而发生转化。
In cells transformed by v-raf, an oncogenic counterpart of the serine/threonine kinase Raf-1, regulatory elements of the c-fospromoter were active under conditions of cell growth or stimulation for which they were inactive in untransformed control cells. This suggests that v-raftransforms by deregulating transcription of early response genes.