Parkinson's disease
Parkinson's disease
复制标题
DOI：
10.1016/s0140-6736(14)61393-3
复制
发表时间：
2015-08-29
期刊：
影响因子：
168.9
通讯作者：
Lang, Anthony E.
中科院分区：
文献类型：
--
作者：
Kalia, Lorraine V.;Lang, Anthony E.
帕金森病是一种神经系统疾病，具有不断发展的复杂性。长期以来，它的特征是与路易体和黑质多巴胺能神经元丢失相关的帕金森病的经典运动特征。然而，帕金森病的神经病学现在被认为是异质性的，具有临床显著的非运动特征。同样，其病理学涉及神经系统的广泛区域、各种神经递质和蛋白质聚集体，而不仅仅是路易体。帕金森病的病因仍然未知，但发展帕金森病的风险不再被视为主要是由于环境因素。相反，帕金森病似乎是遗传和环境因素影响许多基本细胞过程的复杂相互作用的结果。帕金森病的复杂性伴随着临床挑战，包括无法在疾病的最早阶段做出明确的诊断，以及在后期阶段难以管理症状。此外，没有治疗方法可以减缓神经退行性过程。在这次研讨会上，我们回顾了帕金森病的这些复杂性和挑战。
Parkinson's disease is a neurological disorder with evolving layers of complexity. It has long been characterised by the classical motor features of parkinsonism associated with Lewy bodies and loss of dopaminergic neurons in the substantia nigra. However, the symptomatology of Parkinson's disease is now recognised as heterogeneous, with clinically significant non-motor features. Similarly, its pathology involves extensive regions of the nervous system, various neurotransmitters, and protein aggregates other than just Lewy bodies. The cause of Parkinson's disease remains unknown, but risk of developing Parkinson's disease is no longer viewed as primarily due to environmental factors. Instead, Parkinson's disease seems to result from a complicated interplay of genetic and environmental factors affecting numerous fundamental cellular processes. The complexity of Parkinson's disease is accompanied by clinical challenges, including an inability to make a definitive diagnosis at the earliest stages of the disease and difficulties in the management of symptoms at later stages. Furthermore, there are no treatments that slow the neurodegenerative process. In this Seminar, we review these complexities and challenges of Parkinson's disease.