CAROTID-ARTERY INTIMAL-MEDIAL WALL THICKENING AND PLASMA HOMOCYST(E)INE IN ASYMPTOMATIC ADULTS - THE ATHEROSCLEROSIS RISK IN COMMUNITIES STUDY
CAROTID-ARTERY INTIMAL-MEDIAL WALL THICKENING AND PLASMA HOMOCYST(E)INE IN ASYMPTOMATIC ADULTS - THE ATHEROSCLEROSIS RISK IN COMMUNITIES STUDY
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DOI：
10.1161/01.cir.87.4.1107
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发表时间：
1993-04-01
期刊：
影响因子：
37.8
通讯作者：
BOND, G
中科院分区：
文献类型：
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作者：
MALINOW, MR;NIETO, FJ;BOND, G
背景。在某些患有闭塞性动脉疾病的患者中，血浆同型半胱氨酸水平升高。我们将这些发现扩展到无症状的成年人。方法和结果。我们测定了 287 对无症状成年人的血浆同型半胱氨酸水平。病例和对照是根据 B 型超声测量的颈动脉壁内膜中层厚度来定义的。研究对象没有动脉粥样硬化病史，是从 15,800 名年龄在 45 岁至 64 岁之间的男性和女性的概率样本中选出的。内膜内侧颈动脉壁增厚的受试者（病例）的血浆同型半胱氨酸水平高于对照组（p
Background. Plasma levels of homocyst(e)ine are elevated in certain patients with occlusive arterial diseases. We extended these findings to asymptomatic adults.Methods and Results. We determined plasma homocyst(e) ine levels in 287 pairs of asymptomatic adults. Cases and controls were defined on the basis of intimal-medial thickness of the carotid wall as measured by B-mode ultrasound. Study subjects had no history of atherosclerotic disease and were selected from a probability sample of 15,800 men and women between 45 and 64 years old. Subjects with thickened intimal-medial carotid walls (cases) had higher plasma homocyst(e)ine levels than controls (p