Polyphyletic evolution of type II restriction enzymes revisited: two independent sources of second-hand folds revealed
Polyphyletic evolution of type II restriction enzymes revisited: two independent sources of second-hand folds revealed
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DOI：
10.1016/s0968-0004(00)01690-x
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发表时间：
2001-01-01
影响因子：
13.8
通讯作者：
Rychlewski, L
中科院分区：
文献类型：
--
作者：
Bujnicki, JM;Radlinska, M;Rychlewski, L
使用蛋白质序列分析算法，我们预测一些典型的 II 型和 IIS 型限制酶的活性位点具有与“典型”PD-(D/E)xK 超家族显着不同的结构和折叠，这些结果表明它们与 HNH 和 GIY-YIG 超家族的核酸酶有关。
Using algorithms for protein sequence analysis we predict that some of the canonical type II and type IIS restriction enzymes have an active site with a substantially different architecture a nd fold from the "typical" PD-(D/E)xK superfamily, These results suggest that they are related to nucleases from the HNH and GIY-YIG superfamilies.