Anterior chamber-associated immune deviation: a review of the anatomical evidence for the afferent arm of this unusual experimental model of ocular immune responses
Anterior chamber-associated immune deviation: a review of the anatomical evidence for the afferent arm of this unusual experimental model of ocular immune responses
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DOI：
10.1111/j.1442-9071.2005.01044.x
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发表时间：
2005-08-01
影响因子：
4
通讯作者：
McMenamin, PG
中科院分区：
文献类型：
--
作者：
Camelo, S;Kezic, J;McMenamin, PG
前房相关免疫偏差（ACAID）是一种通过向眼球前房注射抗原实验性诱导的耐受动物模型。异常免疫反应既有传入臂，也有传出臂，本文主要讨论传入臂。该范式指出，注射到眼睛前房的抗原被眼内抗原呈递细胞（APCs）内化，然后这些细胞大量迁移到脾脏，诱导调节性T细胞群的分化，进而形成对异常免疫反应的修饰输出臂的基础。然而，眼部APCs或游离抗原向次级淋巴器官的迁移途径尚不清楚。在这篇综述中，我们将讨论抗原（游离或细胞相关）离开眼睛的不同可能传入途径的证据以及分布到次级淋巴器官的模式。
Anterior chamber-associated immune deviation (ACAID) is an animal model of tolerance induced experimentally by the injection of antigen into the anterior chamber of the eye. The unusual deviant immune response has both afferent and efferent arms and it is the former that is the focus of this review. The paradigm states that antigen injected into the anterior chamber of the eye is internalized by intraocular antigen presenting cells (APCs) which then migrate largely to the spleen to induce the differentiation of regulatory T cell populations which in turn form the basis of the modified efferent arm to the deviant immune response. However, the migration routes of ocular APCs or free antigen to the secondary lymphoid organs remain unclear. In this review we will discuss the evidence for different possible afferent routes by which antigen (either free or cell-associated) leaves the eye and the pattern of distribution to secondary lymphoid organs.