Fabrication and dual imaging properties of quantum dot/silica core-shell particles immobilized with gold nanoparticles-猫眼课题宝

DOI：

10.1080/10667857.2018.1502504

发表时间：

2018-07

期刊：

Materials Technology

影响因子：

3.1

通讯作者：

中科院分区：

材料科学4区

文献类型：

作者：

Ting-ting Li;T. Inose;T. Oikawa;M. Tokunaga;K. Hatoyama;K. Nakashima;T. Kamei;K. Gonda;Yoshio Kobayashi

摘要本工作提出了一种制备由量子点、二氧化硅、大Au纳米粒子和小Au纳米粒子组成的核壳纳米粒子的方法。使用正硅酸乙酯（QD/SiO2）的溶胶-凝胶法对QD进行二氧化硅涂覆。AuL和AuS分别由柠檬酸钠和四（羟甲基）氯化鏻在水中还原Au 3+离子制备。利用3-氨丙基三乙氧基硅烷（QD/SiO2/NH 2）在QD/SiO2表面引入氨基。通过将AuL和AuS依次与QD/SiO2/NH 2反应，将AuL和AuS固定在QD/SiO2/NH 2（QD/SiO2/NH 2/AuL/AuS）上。采用巯基化聚乙二醇（PEG）对QD/SiO2/NH 2/AuL/AuS进行表面改性。QD/SiO_2/NH_2/AuL/AuS/PEG胶体溶液可通过其荧光清晰成像。每单位浓度Au（M）的CT值为1.2 × 10 4 HU/M。QD/SiO2/NH 2/AuL/AuS/PEG通过血管在小鼠体内循环，其中一些被捕获并积聚在肝脏和脾脏中。图形摘要

ABSTRACT The present work proposes a preparation method for core-shell nanoparticles composed of quantum dots (QDs), SiO2, large Au nanoparticles (AuL), and small Au nanoparticles (AuS). The QDs were silica-coated with a sol-gel method using tetraethyl orthosilicate (QD/SiO2). AuL and AuS were fabricated by reducing Au3+ ions with sodium citrate and tetrakis(hydroxymethyl)phosphonium chloride in water, respectively. Amino groups were introduced onto QD/SiO2 surface by using (3-aminopropyl)-triethoxysilane (QD/SiO2/NH2). Both AuL and AuS were immobilized on QD/SiO2/NH2 by successively reacting AuL and AuS with QD/SiO2/NH2 (QD/SiO2/NH2/AuL/AuS). Surface modification of QD/SiO2/NH2/AuL/AuS was performed by using polyethylene glycol (PEG) with a thiol group (QD/SiO2/NH2/AuL/AuS/PEG). The QD/SiO2/NH2/AuL/AuS/PEG colloid solution could be clearly imaged via its fluorescence. Its computed tomography (CT) value per unit concentration of Au (M) was 1.2 × 104 HU/M. The QD/SiO2/NH2/AuL/AuS/PEGs were circulated in a mouse through blood vessels, and some of them became trapped and accumulated in the liver and spleen. Graphical Abstract

Fabrication and dual imaging properties of quantum dot/silica core-shell particles immobilized with gold nanoparticles

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