Spin-casting polymer brush films for stimuli-responsiveand anti-fouling surfaces
Spin-casting polymer brush films for stimuli-responsiveand anti-fouling surfaces
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用于刺激响应和防污表面的旋涂聚合物刷膜
DOI：
10.1021/acsami.5b12820
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发表时间：
2016
影响因子：
9.5
通讯作者：
Huang Xiaoyu
中科院分区：
文献类型：
--
作者：
Xu Binbin;Feng Chun;Hu Jianhua;Shi Ping;Gu Guangxin;Wang Lei;Huang Xiaoyu
两亲性聚合物表面改性可以动态改变其物理化学性质，以响应其环境条件的变化;同时，具有分子亲水和疏水补丁的两亲性聚合物涂层，可以有效地减轻生物污损，正在积极探索作为先进的涂层材料。本文中，一系列定义明确的两亲性不对称聚合物刷含有杂侧链，疏水性聚苯乙烯（PS）和亲水性聚（乙二醇）（PEG），采用旋转流延制备均匀的薄膜。通过水接触角、X射线光电子能谱（XPS）、原子力显微镜（AFM）和石英晶体微天平（QCM）等测试手段对薄膜的性质进行了研究。AFM显示所有膜的表面光滑，粗糙度小于2 nm。水接触角和C/O比（XPS）的变化表明，在暴露于选择性溶剂后，PEG或PS链在膜表面富集，指示刺激响应性。通过QCM对蛋白质在PEG功能化表面上的吸附进行了量化，结果证实带有PEG链的两亲聚合物刷膜可以降低或消除蛋白质与材料的相互作用并抵抗蛋白质吸附。使用HaCaT细胞进行细胞粘附实验，发现聚合物刷膜具有良好的粘附性。
Surfaces modified with amphiphilic polymers can dynamically alter their physicochemical properties in response to changes of their environmental conditions; meanwhile, amphiphilic polymer coatings with molecular hydrophilic and hydrophobic patches, which can mitigate biofouling effectively, are being actively explored as advanced coatings for antifouling materials. Herein, a series of well-defined amphiphilic asymmetric polymer brushes containing hetero side chains, hydrophobic polystyrene (PS) and hydrophilic poly(ethylene glycol) (PEG), was employed to prepare uniform thin films by spin-casting. The properties of these films were investigated by water contact angle, X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and quartz crystal microbalance (QCM). AFM showed smooth surfaces for all films with the roughness less than 2 nm. The changes in water contact angle and C/O ratio (XPS) evidenced the enrichment of PEG or PS chains at film surface after exposed to selective solvents, indicative of stimuli- responsiveness. The adsorption of proteins on PEG functionalized surface was quantified by QCM and the results verified that amphiphilic polymer brush films bearing PEG chains could lower or eliminate protein-material interactions and resist to protein adsorption. Cell adhesion experiments were performed by using HaCaT cells and it was found that polymer brush films possess good antifouling ability.