Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model.
Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model.
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DOI：
10.1080/23723556.2018.1472054
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发表时间：
2018
影响因子：
2.1
通讯作者：
Tanuma N
中科院分区：
文献类型：
--
作者：
Sato T;Morita M;Nomura M;Tanuma N
丙酮酸激酶M（PKM）是一种糖酵解酶，其异构体选择影响细胞代谢网络中葡萄糖衍生碳的命运。我们最近开发了新的小鼠品系来研究PKM亚型功能，并将PKM1鉴定为人类肺癌亚组的潜在靶点。这项工作为癌症代谢提供了新的见解。
Isoform selection of pyruvate kinase M (PKM), a glycolytic enzyme, influences fates of glucose-derived carbons in cellular metabolic networks. We recently developed novel mouse lines to study PKM isoform function and identified PKM1 as a potential target in a subset of human lung cancers. This work provides new insight into cancer metabolism.