How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension?
How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension?
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DOI：
10.3389/fphys.2021.705588
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发表时间：
2021
影响因子：
4
通讯作者：
Lu A
中科院分区：
文献类型：
--
作者：
Ning Z;Song Z;Wang C;Peng S;Wan X;Liu Z;Lu A
2型糖尿病（type 2 diabetes mellitus，DM）合并高血压（hypertension，HTN）是半数以上糖尿病患者的常见现象。由于HTN是2型DM患者血管并发症和心血管疾病的预测因子，因此了解2型DM与HTN结合的分子和细胞机制具有重要意义。本文试图从代谢物的角度来了解其作用机制。本文综述了代谢紊乱、代谢紊乱产物在两种疾病中的生物学功能以及代谢紊乱导致2型糖尿病和高血压相关的机制。DM相关代谢紊乱可能参与HTN的发病机制，可能涉及胰岛素、血管紧张素II、交感神经系统和能量重编程，以解决2型DM中代谢紊乱如何影响HTN的发病机制。最近代谢领域与微生物学和免疫学的整合可能提供更广阔的前景。代谢影响免疫功能，并通过能量转换支持免疫细胞分化。细菌产生的不同代谢物也改变了慢性代谢性疾病炎症反应的生物学过程。代谢组学的迅速发展使人们能够更好地了解疾病的过程，这是一个重要的工具，为研究疾病的机制提供了一些见解。作为生物学过程的直接调节剂，二甲双胍被认为是评估涉及疾病的病理机制。
The presence of hypertension (HTN) in type 2 diabetes mellitus (DM) is a common phenomenon in more than half of the diabetic patients. Since HTN constitutes a predictor of vascular complications and cardiovascular disease in type 2 DM patients, it is of significance to understand the molecular and cellular mechanisms of type 2 DM binding to HTN. This review attempts to understand the mechanism via the perspective of the metabolites. It reviewed the metabolic perturbations, the biological function of perturbated metabolites in two diseases, and the mechanism underlying metabolic perturbation that contributed to the connection of type 2 DM and HTN. DM-associated metabolic perturbations may be involved in the pathogenesis of HTN potentially in insulin, angiotensin II, sympathetic nervous system, and the energy reprogramming to address how perturbated metabolites in type 2 DM affect the pathogenesis of HTN. The recent integration of the metabolism field with microbiology and immunology may provide a wider perspective. Metabolism affects immune function and supports immune cell differentiation by the switch of energy. The diverse metabolites produced by bacteria modified the biological process in the inflammatory response of chronic metabolic diseases either. The rapidly evolving metabolomics has enabled to have a better understanding of the process of diseases, which is an important tool for providing some insight into the investigation of diseases mechanism. Metabolites served as direct modulators of biological processes were believed to assess the pathological mechanisms involved in diseases.
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