Reductive DNA cleavage induced by UVA photoirradiation of NADH without oxygen.
Reductive DNA cleavage induced by UVA photoirradiation of NADH without oxygen.
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DOI：
10.1021/ja065073i
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发表时间：
2006-09
影响因子：
15
通讯作者：
Makiko Tanaka;K. Ohkubo;S. Fukuzumi
中科院分区：
文献类型：
--
作者：
Makiko Tanaka;K. Ohkubo;S. Fukuzumi
二氢烟酰胺辅酶（dihydronicotinamide coenzyme，NADH）在许多生物氧化还原过程中起着关键作用，UVA照射可使NADH在无氧条件下发生光致电离、水合电子与DNA反应以及光诱导电子从NADH转移到DNA，从而有效地切割DNA。
UVA irradiation of dihydronicotinamide coenzyme (NADH), which plays a key role in a number of biological redox processes, results in effective DNA cleavage without oxygen via photoionization of NADH and the subsequent reaction of hydrated electron with DNA as well as photoinduced electron transfer from NADH to DNA.