PhoP can activate its target genes in a PhoQ-independent manner
PhoP can activate its target genes in a PhoQ-independent manner
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DOI：
10.1128/jb.186.8.2476-2480.2004
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发表时间：
2004-04-01
影响因子：
3.2
通讯作者：
Soncini, FC
中科院分区：
文献类型：
--
作者：
Lejona, S;Castelli, ME;Soncini, FC
PhoP/PhoQ双组分系统控制沙门氏菌胞外镁耗竭反应先前的研究表明，在没有PhoQ功能的情况下，PhoP无法上调其靶基因。在这项工作中，我们证明，PhoP过表达可以取代PhoQ和磷酸化依赖的激活。高浓度的PhoP或通过磷酸化的活化刺激PhoP自缔合。
The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.