Low molecular weight analogs of coenzyme Q as hydrogen acceptors and donors in systems of the respiratory chain.
Low molecular weight analogs of coenzyme Q as hydrogen acceptors and donors in systems of the respiratory chain.
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辅酶 Q 的低分子量类似物作为呼吸链系统中的氢受体和供体。
DOI：
10.1016/s0006-291x(75)80003-9
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发表时间：
1975
影响因子：
3.1
通讯作者：
Efraim Racker
中科院分区：
文献类型：
--
作者：
Yieh;Robert H. Williams;Karl Folkers;Kam Hung Leung;Efraim Racker
合成了2，3-二甲氧基-5-甲基-6-正戊基-、-6-正癸基-和-6-正十五基-1，4-苯醌，分别作为辅酶Q1、Q2和Q3的类似物。三对醌的6-取代基具有5、10和15个碳原子。这些类似物比类异戊二烯Q's更稳定，并且在生化实验中具有优势。这些低分子量类似物具有不足以模拟较高分子量CoQ（包括CoQ 10）的类脂特性。然而，如果类脂特性不是必需的，戊基和癸基类似物是高度有效的，如通过它们的功能如辅酶Q1和Q2作为氢受体与ETPH颗粒在位点I处进行氧化磷酸化，并且在还原后作为复合物III的氢供体所证明的。
2,3-Dimethoxy-5-methyl-6-n-pentyl-, -6-n-decyl-, and -6-n-pentadecyl-1,4-benzoquinones were synthesized as analogs of coenzyme Q1, Q2, and Q3, respectively. The 6-substituents of the three pairs of quinones have 5, 10, and 15 carbon atoms. These analogs are more stable than the isoprenoid Q's, and have advantages in biochemical experiments. These low molecular weight analogs have inadequate lipoidal characteristics to simulate the higher molecular weight CoQ's including CoQ10. However, if lipoidal characteristics are not essential, the pentyl and decyl analogs are highly effective as evidenced by their functioning like CoQ1and Q2as hydrogen acceptors with ETPH particles for oxidative phosphorylation at site I, and after reduction as hydrogen donors for complex III.