Sleep quality varies as a function of 5-HTTLPR genotype and stress
Sleep quality varies as a function of 5-HTTLPR genotype and stress
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DOI：
10.1097/psy.0b013e31814b8de6
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发表时间：
2007-09-01
影响因子：
3.3
通讯作者：
Williams, Redford B.
中科院分区：
文献类型：
--
作者：
Brummett, Beverly H.;Krystal, Andrew D.;Williams, Redford B.
目的：验证5-HTT基因连锁多态性区域（5-HTTLPR）基因型中等位基因变异与睡眠质量（匹兹堡睡眠质量指数，PSQI）相关的假设，作为主要效应，并受慢性应激的调节。5-羟色胺（5-HT）参与睡眠调节，5-HT转运体（5-HTT）调节5-HT功能。5-HTTLPR中常见的44碱基对缺失（s等位基因）多态性与体外5-HTT转录效率和5-HT摄取降低相关。方法：受试者为142名成年主要照顾者的配偶或父母与痴呆和146名非照顾者控制。受试者接受基因分型并完成PSQI。结果：5-HTTLPR基因型的变异与睡眠质量无显著相关性（p> 0.36）.然而，有一个照顾者X 5-HTTLPR相互作用（p <0.009），这样的s等位基因与睡眠质量较差的照顾者相比，控制。结论：研究结果表明，s等位基因可能会缓和睡眠障碍的慢性压力。
Objective: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. Methods: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. Results: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. Conclusions: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.