Histopathology report of cutaneous melanoma and sentinel lymph node in Europe: a web-based survey by the Dermatopathology Working Group of the European Society of Pathology
Histopathology report of cutaneous melanoma and sentinel lymph node in Europe: a web-based survey by the Dermatopathology Working Group of the European Society of Pathology
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DOI：
10.1007/s00428-009-0763-5
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发表时间：
2009-05-01
期刊：
影响因子：
3.5
通讯作者：
Massi, Daniela
中科院分区：
文献类型：
--
作者：
Batistatou, Anna;Cook, Martin G.;Massi, Daniela
为了调查欧洲病理学家对黑色素瘤的诊断报告，并评估他们目前的做法和对最终报告所需信息的意见，欧洲病理学会皮肤病理学工作组的成员分发了一份基于网络的调查问卷。收集了来自不同病理实验室的 40 份答复（49%）。大多数实验室报告了与原发肿瘤相关的主要预后参数，包括 Breslow 厚度、溃疡的存在和 Clark 水平以及其他特征。 90% 的受访者报告存在退化，但记录项目不同。对于黑色素瘤的前哨淋巴结 (SLN) 活检，常规抗体组包括 S-100、Melan A 和 HMB45。前哨淋巴结的解剖是通过“双壳”或“面包”方法进行的。切割和染色的切片数量各不相同。百分之四十四的受访者报告了胶囊转移的深度，而大多数人报告了最大沉积物的最大尺寸。结果表明，欧洲各个实验室的原发性皮肤黑色素瘤和前哨淋巴结病理报告各不相同。尽管最重要的预后特征已被普遍报道，但影响预后和治疗的关键特征常常被忽略，而其他特征仍需要标准化。
In order to survey the diagnostic reporting of melanomas by European pathologists and assess their current practice and opinions on the information required in the final report, a web-based questionnaire was diffused through the members of the Dermatopathology Working Group of the European Society of Pathology. Forty replies from different pathology laboratories were collected (49%). Main prognostic parameters related to the primary tumor, including Breslow thickness, presence of ulceration, and Clark's level, as well as additional features, are reported by a large majority of laboratories. Presence of regression is reported by 90% of respondents but with different recording items. For sentinel lymph node (SLN) biopsy for melanoma, the conventional panel of antibodies includes S-100, Melan A, and HMB45. Dissection of the SLN is performed by "bivalve" or "bread loaf" approach. The number of sections cut and stained varies. Forty-four percent of respondents report depths of metastases from the capsule, while the majority report maximum dimension of the largest deposit. Results indicate that pathology reports for primary cutaneous melanoma and SLN vary between laboratories across Europe. Although the most important prognostic features are universally reported, key features which impact on prognosis and treatment are often omitted and others still require standardization.