Animal models and programming of the metabolic syndrome
Animal models and programming of the metabolic syndrome
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DOI：
10.1093/bmb/60.1.103
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发表时间：
2001-01-01
影响因子：
6.7
通讯作者：
Hanson, MA
中科院分区：
文献类型：
--
作者：
Bertram, CE;Hanson, MA
本综述的目的是考虑当前的胎儿编程动物模型如何有助于了解成年人的代谢综合征。低出生体重婴儿成年后患心血管和冠心病、高血压、糖尿病和中风的风险增加。许多动物研究证实了胎儿生命期间的事件与随后的成人疾病之间的关联。本综述考虑了这些如何有助于我们理解这种关系，以及它们如何帮助揭示潜在的机制。评估了饮食、药理学、遗传和手术模型的重要性，并评估了它们在预防人类疾病方面的有用性。尽管已经取得了进展，但仍需要使用动物进行进一步的研究，以阐明成人疾病编程所涉及的机制。一旦了解了这些过程，就有可能识别和保护高危个体。
The purpose of this review is to consider how current animal models of fetal programming contribute to knowledge of the metabolic syndrome in adult humans. Low birth weight infants have an increased risk of developing cardiovascular and coronary heart disease, hypertension, diabetes and stroke in adulthood. A number of animal studies confirm the association between events during fetal life and subsequent adult disease. This review considers how these have contributed to our understanding of this relationship, and how they may help to uncover the underlying mechanisms. The importance of dietary, pharmacological, genetic and surgical models is assessed, and their usefulness in the prevention of human disease evaluated. Although progress has been made, further investigations using animals are needed to clarify the mechanisms involved in the programming of adult disease. Once these processes are understood, it may be possible to identify and protect at-risk individuals.