Recent advances in dead cell clearance during acute lung injury and repair.
Recent advances in dead cell clearance during acute lung injury and repair.
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DOI：
10.12703/r/10-33
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Reddy SP
中科院分区：
文献类型：
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作者：
Noone PM;Reddy SP
急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）是临床综合征，其在临床环境中引起显著死亡率，在幸存者中引起发病率，伴随着巨大的医疗保健费用。肺驻留细胞功能障碍/死亡和中性粒细胞肺泡炎伴蛋白性水肿是ALI/ARDS的主要病理特征。虽然对ALI/ARDS发病机制的理解正在取得进展，潜在的治疗方法如他汀类药物治疗，营养策略和间充质细胞治疗正在出现，但ALI/ARDS患者的临床结局仍然不佳。因此，更好地了解肺部驻留细胞死亡和中性粒细胞肺泡炎及其缓解和清除机制可能会提供新的治疗策略，以加速肺修复并改善重症患者的预后。巨噬细胞是正常组织发育和体内平衡以及通过调节炎症和其他细胞过程来调节组织损伤和修复所必需的。虽然巨噬细胞介导的各种功能，在这里，我们回顾最近的死细胞清除（胞饮）机制介导的这些免疫细胞感染性和非感染性肺损伤后维持组织的稳态。
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinical syndromes that cause significant mortality in clinical settings and morbidity among survivors accompanied by huge healthcare costs. Lung-resident cell dysfunction/death and neutrophil alveolitis accompanied by proteinous edema are the main pathological features of ALI/ARDS. While understanding of the mechanisms underlying ALI/ARDS pathogenesis is progressing and potential treatments such as statin therapy, nutritional strategies, and mesenchymal cell therapy are emerging, poor clinical outcomes in ALI/ARDS patients persist. Thus, a better understanding of lung-resident cell death and neutrophil alveolitis and their mitigation and clearance mechanisms may provide new therapeutic strategies to accelerate lung repair and improve outcomes in critically ill patients. Macrophages are required for normal tissue development and homeostasis as well as regulating tissue injury and repair through modulation of inflammation and other cellular processes. While macrophages mediate various functions, here we review recent dead cell clearance (efferocytosis) mechanisms mediated by these immune cells for maintaining tissue homeostasis after infectious and non-infectious lung injury.