Effect of donor pre-mortem hypoxia and hypotension on graft function and start of warm ischemia in donation after cardiac death lung transplantation
Effect of donor pre-mortem hypoxia and hypotension on graft function and start of warm ischemia in donation after cardiac death lung transplantation
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DOI：
10.1016/j.healun.2010.11.010
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发表时间：
2011-04-01
影响因子：
8.9
通讯作者：
Miyoshi, Shinichiro
中科院分区：
文献类型：
--
作者：
Miyoshi, Kentaroh;Oto, Takahiro;Miyoshi, Shinichiro
背景：心源性死亡（DCD）后供体肺热缺血时间（WIT）的起始时间尚未明确定义。我们研究了供体死亡前低血压和缺氧的影响，以确定哪种生理因素是控制性DCD肺移植中WIT发生的决定因素。（1）对照组，不干预，最佳通气，随后心脏停搏;（2）低血压组（HT组），控制性心脏压塞，降低收缩压至
BACKGROUND: The start of warm ischemic time -(WIT) of donor lungs in donation after cardiac death (DCD) is not clearly defined. We investigated the effect of donor pre-mortem hypotension and hypoxia to determine which physiologic factor is the determinant of WIT onset in controlled DCD lung transplantation.METHODS: Twenty mechanically-ventilated donor pigs were placed in 4 groups (n = 5 each) and exposed to each of the pseudo-agonal conditions for 60 minutes: (I) control group, no intervention and optimum ventilation, followed by cardiac arrest; (2) hypotension (HT) group, controlled cardiac tamponade reducing systolic blood pressure to