Antigen expression of human eccrine sweat glands
Antigen expression of human eccrine sweat glands
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DOI：
10.1111/j.1600-0560.2008.01020.x
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发表时间：
2009-03-01
影响因子：
1.7
通讯作者：
Zhang, Lei
中科院分区：
文献类型：
--
作者：
Li, Hai-Hong;Zhou, Gang;Zhang, Lei
汗腺的增殖能力非常有限，因此研究汗腺的修复和再生具有重要意义。通过苏木精-伊红染色观察汗腺的发育，免疫组织化学方法检测汗腺的抗原表达。人汗腺表达细胞角蛋白(CK)7、CK8、CK14、CK18、CK19和上皮膜抗原(EMA)。癌胚抗原(CEA)仅在成人皮肤汗腺表达。发育期和发育期汗腺均有表达Ki67和p63抗原的细胞。表皮生长因子(EGF)主要定位于分泌细胞和导管细胞。部分肌上皮细胞也被抗EGF抗体标记。在大龄胎儿，分泌部管腔内可见EGF阳性染色。人外分泌汗腺表达CK7、CK8、CK14、CK18、CK19、CEA、EMA、Ki67、P63、EGF和EGFR。在皮肤中，CEA可作为汗腺的特异性免疫学标志物。李海华，周刚，傅小柏，张磊.人汗腺的抗原表达.皮肤病理学杂志，2009；36：318-324.(C)布莱克韦尔·蒙克斯加德2008年。
The proliferating abilities of sweat glands are very limited, so researches on the repair and regeneration of sweat glands are important. First of all, we must find out reliable and specific antigen markers of sweat glands.To investigate the antigen expression of human eccrine sweat glands.The development of eccrine sweat glands was investigated by hematoxylin and eosin staining, and the antigen expression was detected by immunohistochemical techniques.Human eccrine sweat glands expressed cytokeratin (CK) 7, CK8, CK14, CK18, CK19 and epithelial membrane antigen (EMA). Carcinoembryonic antigen (CEA) was only expressed in sweat glands in the adult skin. Developing and developed sweat glands all had some cells expressing Ki67 and p63 antigens. Epidermal growth factor (EGF) was mainly localized in the secretory cells and ductal cells. Some myoepithelial cells were also labeled with anti-EGF antibody. In the older fetus, positive staining for EGF was seen in the lumen of the secretory portion. EGF receptor (EGFR) was expressed in the ducts.Human eccrine sweat glands express CK7, CK8, CK14, CK18, CK19, CEA, EMA, Ki67, p63, EGF and EGFR. In skin, CEA can be used as a specific immunological marker of sweat glands.Li H-H, Zhou G, Fu X-B, Zhang L. Antigen expression of human eccrine sweat glands.J Cutan Pathol 2009; 36: 318-324. (C) Blackwell Munksgaard 2008.