Role of lens vault in subtypes of angle closure in Iranian subjects
Role of lens vault in subtypes of angle closure in Iranian subjects
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作者：
Moghimi, S.;Vahedian, Z.;Lin, S.
目的-本研究的目的是量化前房（AC）参数，并使用前段光学相干断层扫描（AS-OCT）确定不同亚型的闭角病中具有夸大的透镜穹窿（LV）的眼睛的比例。急性闭角型青光眼（AAC）40眼，原发性闭角型青光眼（PACG）39眼，原发性可疑闭角型青光眼（PACS）36眼。进行了完整的眼科检查，包括前房角镜检查、A扫描生物测量和AS-OCT。应用AS-OCT测量虹膜厚度（IT）、左房厚度（LV）、角膜内皮与鼻颞侧巩膜棘连线距离的1/3以上即为左房扩大（P = 0.01），更大的虹膜曲率（I曲线; P = 0.01），更高的LV（P = 0.02）与PACS和PACG眼睛相比。在距巩膜距750 μ m处，三组的平均IT无统计学显著差异（P = 0.45）。在AAC、PACG和PACS的对侧眼中分别有67.5%、35.9%和40%的左心室肥大（P = 0.008），对侧眼与PACG的比值比为1.92（P = 0.005），对侧眼与PACS的比值比为1.68（P = 0.01）。结论左室肥厚在AAC患者的对侧眼中普遍存在。与PACG和PACS相比，这些眼睛的AC深度较浅，I曲线较大，LV较高。
Purpose The purpose of this study is to quantify anterior chamber (AC) parameters and to determine the proportion of eyes with exaggerated lens vault (LV) in different subtypes of angle closure disease using anterior segment optical coherence tomography (AS-OCT).Patients and methods In this prospective study, 115 eyes of 115 Iranian patients with angle closure disease were included and categorized into three groups: (1) fellow eyes of acute angle closure (AAC; 40 eyes); (2) primary angle closure glaucoma (PACG; 39 eyes); and (3) primary angle closure suspect (PACS; 36 eyes). Complete ophthalmic examination including gonioscopy, A-scan biometry, and AS-OCT were performed. Angle parameters, LV, and iris thickness (IT) were measured using AS-OCT. An exaggerated LV was defined as LV more than one-third the distance between the corneal endothelium and a line drawn to connect the nasal and temporal scleral spurs.Results Fellow eyes of AAC had the shallower AC (P = 0.01), greater iris curvature (I-curve; P = 0.01), and higher LV (P = 0.02) as compared with PACS and PACG eyes. There was no statistically significant difference in the mean IT at 750 mu m from scleral spur among the three groups (P = 0.45). Exaggerated LV was found in 67.5, 35.9, and 40% of fellow eyes of AAC, PACG, and PACS, respectively, (P = 0.008) with an odds ratio of 1.92 (P = 0.005) for fellow vs PACG and 1.68 (P = 0.01) for fellow vs PACS. Conclusions Exaggerated LV is highly prevalent in fellow eyes of AAC. These eyes have shallower AC depth, greater I-curve, and higher LV when compared with PACG and PACS.