Peptidoglycan Composition in Neisseria.
Peptidoglycan Composition in Neisseria.
复制标题
奈瑟菌中的肽聚糖组成。
DOI：
10.1007/978-1-4939-9496-0_8
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Dillard,JosephP
中科院分区：
文献类型：
--
作者：
Schaub,RyanE;Dillard,JosephP
The composition ofNeisseriapeptidoglycan has been of scientific interest for over four decades. Initial investigations focused on discovering the mechanisms causing rising rates of antibiotic resistance inN. gonorrhoeaeby determining differences in peptidoglycan composition in penicillin susceptible and resistant strains. The discovery that cytotoxic peptidoglycan fragments are also released byNeisseriafurthered the interest in peptidoglycan composition. This method describes the purification, enzymatic degradation, and separation of peptidoglycan fragments by high-performance liquid chromatography (HPLC). It also describes the preparation of samples so that they can be positively identified by mass spectrometry.
