The effectiveness of gabapentin and exercises in the treatment of carpal tunnel syndrome: a randomized clinical trial
The effectiveness of gabapentin and exercises in the treatment of carpal tunnel syndrome: a randomized clinical trial
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DOI：
10.12965/jer.1836420.210
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发表时间：
2018-12-01
影响因子：
1.9
通讯作者：
Salehi, Shahin
中科院分区：
文献类型：
--
作者：
Hesami, Omid;Haghighatzadeh, Mahsa;Salehi, Shahin
腕管综合征（CTS）是由于无力和疼痛而放弃劳动的原因之一。本研究的目的是评价加巴喷丁和运动训练治疗CTS的有效性，并比较它们的效果。这项单盲临床试验是在伊玛目侯赛因医院的电诊断（EDX）单位的患者中进行的。患者随机分为四组：对照组使用夜间夹板作为批准的治疗;每晚服用加巴喷丁300毫克，并使用夜间夹板神经和肌腱滑行练习，并使用夜间夹板，每晚服用加巴喷丁300毫克，在基线时，对所有患者进行四项指标的评估，包括波士顿腕管问卷、视觉模拟量表（VAS）、患手的捏和握力。在干预开始一个月后，对参与者进行了重新评估，并对四项指标进行了比较。与仅使用夜间夹板的对照组相比，使用夜间夹板沿着运动和加巴喷丁显著改善中度CTS的VAS、捏和握力，但在轻度CTS中，握力与对照组相比并不显著更高（P=0.048）。本研究的结果表明，在轻度CTS中单独使用夹板是适当且充分的治疗，然而，在中度CTS中，与单独使用夹板相比，接受加巴喷丁沿着锻炼和夹板治疗显示出更好的治疗结果。
Carpal tunnel syndrome (CTS) is one of the reasons for labor abandonment due to inability and pain. The aim of this study was to evaluate the effectiveness of gabapentin and exercise training in the treatment of CTS and compare their effects. This single-blind clinical trial was conducted on patients referred to the Imam Hossein hospital's electrodiagnostic (EDX) unit The patients randomly assigned into four groups: using nocturnal splint as an approved treatment in the control group; taking 300-mg gabapentin per night and using nocturnal splint nerve and tendon gliding exercises and using nocturnal splint, and taking 300-mg gabapentin per night, performing same exercise as group 3 and using nocturnal splint At baseline, four indicators were assessed in all patients, including the Boston carpal tunnel questionnaire, visual analogue scale (VAS), pinch and grip strength of the affected hand. One month after the beginning of intervention, participants were reassessed and compared for each of the four indicators. Using nocturnal splint along with exercise and gabapentin significantly improved VAS, pinch and grip strength in moderate CTS compared to control group that only used nocturnal splint However in mild CTS, grip strength was not significantly higher compared to control group (P=0.048). Results of this study showed that use of splint alone in mild CTS is an appropriate and sufficient treatment however, in moderate CTS, receiving gabapentin along with exercise and splinting showed better treatment results compared to splinting alone.