Common White Matter Microstructure Alterations in Pediatric Motor and Attention Disorders
Common White Matter Microstructure Alterations in Pediatric Motor and Attention Disorders
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DOI：
10.1016/j.jpeds.2014.01.018
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发表时间：
2014-05-01
影响因子：
5.1
通讯作者：
Dewey, Deborah
中科院分区：
文献类型：
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作者：
Langevin, Lisa Marie;MacMaster, Frank P.;Dewey, Deborah
目的研究孤立性或并发发展性协调障碍和/或注意缺陷/多动障碍（ADHD）患儿与正常对照组相比的白质变化特征，并确定各组在运动和注意任务上的差异是否可以用扩散张量成像（DTI）测量的差异来解释。研究设计在一组患有发育协调障碍、多动症或发育协调障碍+多动症的儿童（n = 85）中，我们检查了涉及注意力和运动过程的3个主要白质束。使用DTI，对胼胝体、上纵束和扣带的白质完整性进行了分析。分数各向异性（FA）、平均扩散系数、径向扩散系数和轴向扩散系数的差异采用方差分析分析。使用标准化测试评估运动和注意力功能，并与DTI测量相关。结果ADHD儿童的胼胝体额叶区FA减少（P = 0.039），而发育协调障碍儿童的顶叶下胼胝体区域FA减少（P = 0.040），以及左上纵束FA减少（P = 0.026）。并发发育协调障碍+ADHD儿童额叶和顶叶白质完整性均受到影响（P = 0.029; 0.046）。FA与运动和注意力评估得分呈区域特异性正相关。结论胼胝体的改变是运动和注意功能障碍的基础。这些变化在功能和区域上是不同的，可能反映了儿童运动和注意力障碍的神经生物学基础。
Objective To characterize white matter alterations in children with isolated or concurrent developmental coordination disorder and/or attention-deficit/hyperactivity disorder (ADHD) compared with typically-developing controls, and to determine whether group differences on motor and attention tasks could be explained by differences in diffusion tensor imaging (DTI) measures.Study design In a cohort of children (n = 85) with developmental coordination disorder, ADHD, or combined developmental coordination disorder+ADHD, we examined 3 major white matter tracts involved in attention and motor processes. Using DTI, the corpus callosum, superior longitudinal fasciculus, and cingulum were analyzed with respect to measures of white matter integrity. Differences in fractional anisotropy (FA), mean diffusivity, radial diffusivity, and axial diffusivity were analyzed using ANOVA. Motor and attentional functioning was assessed using standardized tests, and correlated to DTI measures.Results FA reductions were noted in the frontal regions of the corpus callosum for children with ADHD (P = .039), whereas children with developmental coordination disorder displayed similar reductions in regions of the corpus callosum underlying parietal brain regions (P = .040), as well as the left superior longitudinal fasciculus (P = .026). White matter integrity was impacted in both frontal and parietal regions for children with comorbid developmental coordination disorder+ADHD (P = .029; .046). FA was positively correlated with scores on both motor and attentional assessments in a region-specific manner.Conclusion Our findings suggest that alterations in the corpus callosum underlie difficulties in motor and attention functioning. These changes are functionally and regionally distinct and could reflect a neurobiological basis for motor and attention disorders in children.