Characterizing multiple independent behavioral correlates of cell firing in freely moving animals.
Characterizing multiple independent behavioral correlates of cell firing in freely moving animals.
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自由移动的动物对行为状态的不同抽样阻碍了我们通过引入行为变量之间的依赖关系来将神经元放电率与行为变量联系起来的能力。我们特别考虑动物的位置和方向，尽管我们的分析可能会推广到其他行为变量，如移动速度。提出了一种最大似然方法，用于产生与多个独立原因有关的独立直方图的估计。实例表明，该方法可以用来避免标准分析产生的位置和头部方向细胞放电的人为行为相关性；可以用来表征第三种细胞类型(Cacucci等人提交的)中位置和方向的独立影响；以及证明头部方向细胞定向放电的位置独立性。
The heterogeneous sampling of behavioral states by freely moving animals hinders our ability to relate neuronal firing rates to behavioral variables by introducing dependencies between them. We specifically consider the animal’s location and orientation, although our analyses may generalize to other behavioral variables such as speed of movement. A maximum-likelihood approach is presented for producing estimates of the separate histograms relating firing rate to multiple independent causes. Examples show that the method can be used to avoid the artefactual behavioral correlates of place and head-direction cell firing produced by standard analyses; to characterize the independent influences of both location and orientation in a third cell type (Cacucci at al., submitted); and to demonstrate the location-independence of the directional firing of head-direction cells.