Off-line processing: Reciprocal interactions between declarative and procedural memories
Off-line processing: Reciprocal interactions between declarative and procedural memories
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DOI：
10.1523/jneurosci.2799-07.2007
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发表时间：
2007-09-26
影响因子：
5.3
通讯作者：
Robertson, Edwin M.
中科院分区：
文献类型：
--
作者：
Brown, Rachel M.;Robertson, Edwin M.
声明的获得（即，事实）和程序（即，技能）存储器可以由独立的系统支持。在记忆获取之后，当在整合期间离线处理记忆时，可能存在相同的组织。可替代地，存储器整合可以由交互式系统支持。后一种互动组织预测陈述性记忆和程序性记忆之间的干扰。在这里，我们表明，程序性巩固，表示为离线运动技能的改善，可以通过清醒时的陈述性学习来阻止，但不会超过一夜的睡眠。程序性巩固障碍的程度与参与者的陈述性单词回忆相关。同样，在另一个实验中，发现了相互关系：清醒时的程序性学习阻止了陈述性巩固，但在一夜睡眠中却没有。陈述性回忆的减少与参与者的程序性学习有关。这些结果挑战了固定的独立记忆系统的概念;相反，他们提出了一个动态的关系，当巩固发生调制，有时允许记忆系统之间的相互作用。
The acquisition of declarative (i.e., facts) and procedural (i.e., skills) memories may be supported by independent systems. This same organization may exist, after memory acquisition, when memories are processed off-line during consolidation. Alternatively, memory consolidation may be supported by interactive systems. This latter interactive organization predicts interference between declarative and procedural memories. Here, we show that procedural consolidation, expressed as an off-line motor skill improvement, can be blocked by declarative learning over wake, but not over a night of sleep. The extent of the blockade on procedural consolidation was correlated to participants' declarative word recall. Similarly, in another experiment, the reciprocal relationship was found: declarative consolidation was blocked by procedural learning over wake, but not over a night of sleep. The decrease in declarative recall was correlated to participants' procedural learning. These results challenge the concept of fixed independent memory systems; instead, they suggest a dynamic relationship, modulated by when consolidation takes place, allowing at times for a reciprocal interaction between memory systems.