Magnetic Source Imaging of Cortical Dysfunction in Amyotrophic Lateral Sclerosis
Magnetic Source Imaging of Cortical Dysfunction in Amyotrophic Lateral Sclerosis
复制标题
肌萎缩侧索硬化症皮质功能障碍的磁源成像
DOI：
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发表时间：
2008
影响因子：
3
通讯作者：
Richard Smith
中科院分区：
文献类型：
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作者：
R. Boyajian;C. Amo;S. Otis;J. Romine;Richard Smith
Boyajian RA，Amo C，奥蒂斯SM，Romine JS，Smith RA：肌萎缩侧索硬化症皮质功能障碍的磁源成像。美国物理医学康复杂志2008;87：427-437。目的：目的是确定磁源成像是否可以识别肌萎缩侧索硬化症（ALS）患者皮质受累的特征，并确定该方法是否可以提供与疾病过程相关的功能异常的见解。设计：采用全头148通道脑磁图（MEG）记录自发脑活动，以寻找无痴呆的ALS患者的局灶性δ-θ（1-7 Hz）放电的局部偶极源。局部慢波偶极子映射和计数解剖脑区，由MRI定义，并与修订的ALS功能评定量表（ALS残疾的功能测量）。在一项子研究中，研究了一名可能患有上肢运动性失用症的ALS患者的皮层激活介导有目的运动的缺陷。结果：MEG显示7/7例ALS患者的局部慢波偶极子源，包括2例最近诊断的患者（0/8例年龄相似的对照）。在所有7名ALS患者中，偶极源发生器的系统脑映射是可能的。慢波爆发产生于额叶、颞叶和顶叶皮质，而不是枕叶。扣带回慢波偶极子的密度与上肢残疾的严重程度相关的功能性ALS措施判断。在单侧肢体失用症的子研究患者中进行的进一步磁源成像显示，有目的运动的中枢处理异常，对侧次级运动区产生慢波的M2缺失。结论：这项探索性研究记录了ALS患者广泛的皮质功能障碍，包括那些最近发病的患者。脑磁图可能是一个强大的新工具，研究皮质功能障碍的贡献，运动障碍的特点，疾病的过程。
Boyajian RA, Amo C, Otis SM, Romine JS, Smith RA: Magnetic source imaging of cortical dysfunction in amyotrophic lateral sclerosis. Am J Phys Med Rehabil 2008;87:427–437. Objective:The goal was to determine whether magnetic source imaging could identify a signature for cortical involvement in patients with amyotrophic lateral sclerosis (ALS), and to determine whether the method might provide insight into functional abnormalities associated with the disease process. Design:Spontaneous brain activity recordings from whole-head 148-channel magnetoencephalography (MEG) were employed to look for localized dipolar sources of focal delta-theta (1–7 Hz) discharges in patients with ALS without dementia. Localized slow wave dipoles were mapped and counted by anatomic brain region, defined by MRI, and correlated against the revised ALS functional rating scale (a functional measure of ALS disability). In a substudy, defects in cortical activations mediating purposeful movement were investigated in an ALS patient with probable motor apraxia of an upper limb. Results:MEG revealed localized slow wave dipole sources in 7/7 ALS patients, including two recently diagnosed patients (0/8 age-similar controls). Systematic brain mapping of dipole source generators was possible in all seven ALS patients. The slow wave bursts were being generated from frontal, temporal, and parietal cortices, but not from occipital areas. The density of slow wave dipoles in cingulate gyrus correlated with the severity of upper-extremity disability as judged by the functional ALS measure. Further magnetic source imaging in the substudy patient with unilateral limb apraxia revealed abnormal central processing of purposeful movement with absent M2 in the contralateral secondary motor areas generating slow waves. Conclusions:This exploratory study documents widespread cortical dysfunction in patients with ALS, including those with recent onset of their disease. MEG is likely to be a powerful new tool for researching the contribution of cortical dysfunction to the motor disability that characterizes the disease process.
DOI：
10.1016/s0013-4694(97)00043-6
发表时间：
1997-10-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Okada, YC;Wu, J;Kyuhou, S
通讯作者：
Kyuhou, S