The application of magnetic resonance imaging to the study of experimental cerebral ischaemia.
The application of magnetic resonance imaging to the study of experimental cerebral ischaemia.
复制标题
磁共振成像在实验性脑缺血研究中的应用
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
J. E. Cremer
中科院分区：
文献类型：
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作者：
N. van Bruggen;T. Roberts;J. E. Cremer
磁共振成像（MRI）领域的最新发展为疾病的研究提供了新的机会。本文旨在说明这些进展如何使MRI成为研究脑缺血病理和生理的有力工具。重点将放在MR研究者可支配的新技术上。这些技术包括监测脑血流量和容量变化的技术;研究脑缺血急性病理学的弥散加权成像;以及对组织血氧水平变化敏感的技术，这些技术提供了一种完全无创的评估脑血流动力学的方法，包括充血和CO2反应性。特别提到的能力，这种技术，以确定缺血组织之前，不可逆的损害，将进行讨论，并为制药研究和潜在的治疗的影响。详细的技术描述的核磁共振理论是避免，我们集中在应用MRI询问脑缺血的病理生理。
Recent developments in the field of magnetic resonance imaging (MRI) have opened up new opportunities in the investigation of disease. This review seeks to illustrate how some of these advances have made MRI a powerful tool with which to study the pathology and physiology of cerebral ischaemia. Emphasis will be placed on new techniques at the disposal of the MR investigator. These include techniques to monitor alterations in cerebral blood flow and volume; diffusion-weighted imaging to investigate the acute pathology of cerebral ischaemia; and techniques sensitive to alteration in tissue blood oxygenation levels that provide a wholly noninvasive means of assessing cerebral haemodynamics, including hyperaemia and CO2 reactivity. Particular reference to the ability of such techniques to identify ischaemic tissue prior to irreversible damage will be made, and the implication for pharmaceutical research and potential therapy will be discussed. A detailed technical description of nuclear MR theory is avoided, and we have concentrated on the application of MRI to interrogate the pathophysiology of cerebral ischaemia.