ELECTRIC-DIPOLE TRACING IN THE BRAIN BY MEANS OF THE BOUNDARY ELEMENT METHOD AND ITS ACCURACY
ELECTRIC-DIPOLE TRACING IN THE BRAIN BY MEANS OF THE BOUNDARY ELEMENT METHOD AND ITS ACCURACY
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DOI：
10.1109/tbme.1987.326056
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发表时间：
1987-06-01
影响因子：
4.6
通讯作者：
SATO, T
中科院分区：
文献类型：
--
作者：
HE, B;MUSHA, T;SATO, T
本文提出了一种用边界元法从头皮电位分布确定脑电偶极子位置的方法，该方法考虑了头部的真实的几何形状，并假定其电导率是均匀的。该方法的准确性进行了评估，通过动物实验与猫，其中一个电流偶极子是人工产生的大脑。估计的偶极子位置与真实位置的偏差不是随机的，而是系统性的（可能是由于不均匀的电导率分布）。数值计算发现，在头骨中的空腔干扰的逆解，特别是当偶极子是面向空腔。在体内测试的方法也做了初级体感诱发电位作为对正中神经刺激的猫和肌阵挛脑电图的反应。虽然进行了齐次近似，但这并不改变本方法所得结果的意义。
A method of localizing an electrical dipole in the brain from the scalp potential distribution has been developed with the aid of the boundary element method, in which a real geometry of the head is exactly taken into account and homogeneous electrical conductivity is assumed. Accuracy of the method was evaluated through animal experiments with a cat in which a current dipole was artificially generated in the brain. Deviation of the estimated dipole location from the true one was not random, but rather systematic (probably due to in-homogeneous conductivity distribution). It is numerically found that cavities in the skull disturb the inverse solution especially when the dipole is oriented toward the cavities. In vivo tests of the method were also done for primary somatosensory evoked potentials as a response to median nerve stimulation of a cat and myoclonic EEG. Although the homogeneous approximation was made, it does not change the significance of the results obtained by the present method.