Neuroimmune Mechanisms Underlying Neuropathic Pain: The Potential Role of TNF-α-Necroptosis Pathway.
Neuroimmune Mechanisms Underlying Neuropathic Pain: The Potential Role of TNF-α-Necroptosis Pathway.
复制标题
神经性疼痛背后的神经免疫机制：TNF-α-坏死性凋亡途径的潜在作用
DOI：
10.3390/ijms23137191
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发表时间：
2022-06-28
影响因子：
5.6
通讯作者：
Zang, Ying
中科院分区：
文献类型：
--
作者：
Duan, Yi-Wen;Chen, Shao-Xia;Li, Qiao-Yun;Zang, Ying
神经病理性疼痛背后的神经免疫机制已得到广泛研究。肿瘤坏死因子-α（TNF-α）是一种关键的促炎细胞因子，可引发细胞因子风暴，并在疼痛相关通路中刺激一系列其他细胞因子，它通过促进外周（初级传入神经）和中枢（脊髓）敏化来诱导和调节神经病理性疼痛。从功能上讲，TNF-α通过诱导炎症反应以及两种程序性细胞死亡机制（细胞凋亡和坏死性凋亡）来控制细胞存活与死亡之间的平衡。坏死性凋亡作为一种新型程序性细胞死亡形式，正受到越来越多的关注，它可能引发神经炎症，进而加剧神经病理性疼痛。慢性疼痛通常伴随着不良的疼痛相关情绪反应和认知障碍。在诸如前扣带回皮质（ACC）和海马体等脊髓上结构中，TNF-α的过量产生在疼痛相关情绪障碍和记忆缺陷中发挥着重要作用，同时也参与疼痛传导的调节。目前，关于TNF-α - 坏死性凋亡通路在疼痛相关疾病中作用的研究较为匮乏。本综述基于该通路在与其他神经退行性疾病相关的焦虑、抑郁和记忆缺陷中的作用，指出了其在疼痛调节方面重要的研究前景。此外，我们总结了与TNF-α介导的神经病理性疼痛潜在机制相关的研究，并详细讨论了TNF-α - 坏死性凋亡通路的作用，这可能为未来的治疗干预提供一条途径。
The neuroimmune mechanism underlying neuropathic pain has been extensively studied. Tumor necrosis factor-alpha (TNF-α), a key pro-inflammatory cytokine that drives cytokine storm and stimulates a cascade of other cytokines in pain-related pathways, induces and modulates neuropathic pain by facilitating peripheral (primary afferents) and central (spinal cord) sensitization. Functionally, TNF-α controls the balance between cell survival and death by inducing an inflammatory response and two programmed cell death mechanisms (apoptosis and necroptosis). Necroptosis, a novel form of programmed cell death, is receiving increasing attraction and may trigger neuroinflammation to promote neuropathic pain. Chronic pain is often accompanied by adverse pain-associated emotional reactions and cognitive disorders. Overproduction of TNF-α in supraspinal structures such as the anterior cingulate cortex (ACC) and hippocampus plays an important role in pain-associated emotional disorders and memory deficits and also participates in the modulation of pain transduction. At present, studies reporting on the role of the TNF-α–necroptosis pathway in pain-related disorders are lacking. This review indicates the important research prospects of this pathway in pain modulation based on its role in anxiety, depression and memory deficits associated with other neurodegenerative diseases. In addition, we have summarized studies related to the underlying mechanisms of neuropathic pain mediated by TNF-α and discussed the role of the TNF-α–necroptosis pathway in detail, which may represent an avenue for future therapeutic intervention.
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DOI：
10.1093/brain/awaa208
发表时间：
2020-08-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Chen, Lubin;Huang, Jianying;Dib-Hajj, Sulayman D
通讯作者：
Dib-Hajj, Sulayman D
影响因子：
25
作者：
Caccamo, Antonella;Branca, Caterina;Oddo, Salvatore
通讯作者：
Oddo, Salvatore
影响因子：
10.6
作者：
Barthas, Florent;Humo, Muris;Yalcin, Ipek
通讯作者：
Yalcin, Ipek
影响因子：
4.7
作者：
Chen, Shao-Xia;Wang, Shao-Kun;Zang, Ying
通讯作者：
Zang, Ying
影响因子：
4.8
作者：
Chan, FKM;Shisler, J;Lenardo, MJ
通讯作者：
Lenardo, MJ