Central serotonin metabolism and frequency of depression
Central serotonin metabolism and frequency of depression
复制标题
中枢血清素代谢和抑郁症频率
DOI：
10.1016/0165-1781(79)90002-7
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发表时间：
1979
影响因子：
11.3
通讯作者：
S. Haan
中科院分区：
文献类型：
--
作者：
H. Praag;S. Haan
中枢性5-羟色胺(5-羟色胺；5-羟色胺)代谢可在部分重症(内源性、原发性)抑郁症患者中受到干扰。据推测，这些干扰并不是由大萧条引起的，而是与之相关的诱因而非因果关系。后一种说法是基于两个观察结果。首先，在大多数患者中，5-羟色胺紊乱在抑郁缓解后持续存在。其次，5-羟色氨酸似乎具有预防价值，特别是对于中枢5-羟色胺代谢持续异常的患者。在这项研究中，我们从另一个角度探讨了5-羟色胺紊乱是抑郁症发生的易感因素的假设。如果这一假设是正确的，那么有持续性5-羟色胺紊乱的抑郁症患者应该比没有明显5-羟色胺紊乱的抑郁症患者有更高的抑郁发生率。这一点确实得到了证明。5-羟基吲哚乙酸水平较低的先证者的家庭成员也是如此。没有家庭成员的脑脊液数据。已报道的发现有力地支持了易感性假说。
Central serotonin (5-hydroxytryptamine; 5-HT) metabolism can be disturbed in a subgroup of patients with vital (endogenous, primary) depression. Presumably these disturbances do not result from the depression and have a predisposing rather than a causative relationship to it. This latter statement is based on two observations. First, in a majority of patients, the 5-HT disturbances persist after depression has abated. Secondly, 5-hydroxytryptophan seems to have prophylactic value, in particular in patients with persistent abnormalities in central 5-HT metabolism. In this study we approached the hypothesis that 5-HT disturbances are a predisposing factor to the occurence of depression from still another perspective. If this hypothesis is correct, then depressive patients with persistent 5-HT disturbances should have higher frequencies of depression than depressive patients without demonstrable 5-HT disturbances. This was indeed demonstrated. The same was true for family members of probands with low levels of 5-hydroxyindoleacetic acid. No cerebrospinal fluid data are available for family members. The reported findings strongly support the predisposition hypothesis.