Experimental sensory ganglionectomy by way of suicide axoplasmic transport.
Experimental sensory ganglionectomy by way of suicide axoplasmic transport.
复制标题
通过自杀轴浆运输进行实验性感觉神经节切除术。
DOI：
10.3171/jns.1984.60.1.0108
复制
发表时间：
1984
影响因子：
4.1
通讯作者：
H. Konno
中科院分区：
文献类型：
--
作者：
T. Yamamoto;Y. Iwasaki;H. Konno
为了通过逆行轴浆运输选择性破坏感觉神经节细胞，将蓖麻凝集素（RCA 60 和 RCA 120）（来自蓖麻子的剧毒凝集素）中的一种或另一种局部应用于大鼠三叉神经分支（颏神经和眶上神经）的近端残端或坐骨神经。几天之内，与应用 RCA 的神经相关的感觉神经节细胞发生弥散性色谱溶解，随后神经元细胞体溶解。由此产生的初级传入纤维的华勒变性可以在脑干内追踪到，如果将 RCA 应用于坐骨神经，则可以在脊髓内追踪到。这一观察结果表明，周围神经的中枢对应部分可以通过逆行轴浆运输的方式有效地破坏，而不直接攻击目标结构，因此这种方法可以在未来用作控制各种疼痛问题的手段。
In attempts to destroy selectively the sensory ganglion cells via retrograde axoplasmic transport, either one or the other of the Ricinus communis agglutinins (RCA 60 and RCA 120), highly toxic lectins from castor beans, was topically applied to the proximal stump of the rat trigeminal branches (the mental and supraorbital nerves) or to the sciatic nerve. Within several days, the sensory ganglion cells associated with the nerve to which RCA was applied developed diffuse chromatolysis and subsequent dissolution of neuronal cell bodies. The resultant Wallerian degeneration of their primary afferent fibers could be traced within the brain stem and, in cases with RCA application to the sciatic nerve, within the spinal cord. This observation implies that the central counterpart of the peripheral nerve may be effectively destroyed by way of retrograde axoplasmic transport without direct attack on the target structure, and thus this method may be utilized in the future as a means for controlling various pain problems.